Tissue plasminogen activator-based nanothrombolysis for ischemic stroke
نویسندگان
چکیده
منابع مشابه
The Outcome of Treatment With Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke
Background: Thrombolytic therapy is the recommended treatment of acute ischemic stroke. It is crucial to evaluate the treatment results with recombinant Tissue Plasminogen Activator (r-TPA) in patients with acute stroke. Objectives: This study aimed to evaluate treatment outcomes with r-TPA in patients with acute stroke in a referral stroke center in Iran. Materials & Methods: In this retrosp...
متن کاملRecombinant Tissue-Type Plasminogen Activator (Alteplase) for Ischemic Stroke
THE FOOD AND DRUG ADMINIStration (FDA) approval in June 1996 of intravenous recombinant tissue-type plasminogen activator (rt-PA) for patients with acute ischemic stroke treated within 3 hours of symptom onset marked a historic first step in treating this devastating disease. This approval was primarily based on the results of the National Institute of Neurologic Disorders (NINDS) trials (1 and...
متن کاملCost-effectiveness of tissue plasminogen activator for acute ischemic stroke.
Dates to which data relate Effectiveness and resource use data were extracted from NINDS rt-PA Stroke Trial conducted between January 1991 and October 1994, the results of which were published in 1995. Clinical probabilities relating to the epidemiological course of events were obtained from studies published between 1982 and 1997. The utility values related to different discharge states were b...
متن کاملTissue-type plasminogen activator for acute ischemic stroke.
BACKGROUND AND PURPOSE Several studies are currently evaluating tissue-type plasminogen activator (TPA) as a potential therapy in acute ischemic stroke. The possibility of inducing intracranial hematomas, however, introduces an important concern into ultimate evaluation of risk and benefit. This retrospective analysis sought to identify factors associated with intracranial hematoma formation in...
متن کاملpharmacotherapy updates of recombinant tissue plasminogen activator (r-tpa) in acute ischemic stroke
conclusions due to considerable inter- and intra- heterogeneity among studies performed by other centers such as differences in study project, background, and population features, determining a pharmacotherapy model based on safe implementation of treatments in stroke or sits seem advantageous. results age, time of onset, systolic blood pressure, diabetes, stroke severity, co-morbidities and pr...
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ژورنال
عنوان ژورنال: Expert Opinion on Drug Delivery
سال: 2017
ISSN: 1742-5247,1744-7593
DOI: 10.1080/17425247.2018.1384464